Intermittent parathyroid hormone improve bone microarchitecture of the mandible and femoral head in ovariectomized rats
Identifieur interne : 000197 ( Main/Exploration ); précédent : 000196; suivant : 000198Intermittent parathyroid hormone improve bone microarchitecture of the mandible and femoral head in ovariectomized rats
Auteurs : Ying-Ju Chen [Taïwan] ; Shun-Ping Wang [Taïwan] ; Fu-Chou Cheng [Taïwan] ; Pei-Yu Hsu [Taïwan] ; Yu-Fen Li [Taïwan] ; Jay Wu [Taïwan] ; Heng-Li Huang [Taïwan] ; Ming-Tzu Tsai [Taïwan] ; Jui-Ting Hsu [Taïwan]Source :
- BMC Musculoskeletal Disorders [ 1471-2474 ] ; 2017.
Abstract
Intermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip. However, whether it can be used to treat osteoporosis of the mandible is unclear. The purpose of this study was to explore the influence of applying intermittent PTH to ovariectomized rats on the trabecular bone microarchitecture of the mandible and femoral head.
Eighteen female rats were divided into three groups: the healthy group, ovariectomized (OVX) group, and OVX + PTH group. The OVX group and OVX + PTH group had an OVX at 8 weeks of age. The OVX + PTH group received intermittent PTH therapy for 12 weeks. The mandibles and femurs of all rats were removed at 20 weeks and were then scanned using microcomputed tomography (micro-CT).
From the micro-CT analysis, the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The bone volume fraction and trabecular thickness in the OVX group were lower than those in the healthy group. (2) The bone volume fraction and trabecular thickness in the OVX + PTH group approximated those in the healthy group.
The conclusions of this study regarding the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The BV/TV and TbTh in the OVX group were lower than those in the healthy group. (2) The BV/TV and TbTh in the OVX + PTH group approximated those in the healthy group, therefore, intermittent PTH displayed high efficacy for treating femoral or mandibular deterioration of bone microstructure resulting from loss of ovarian function. Osteoporosis of the femur or mandible in the rats was ameliorated by intermittent PTH therapy.
Url:
DOI: 10.1186/s12891-017-1530-4
PubMed: 28438150
PubMed Central: 5404672
Affiliations:
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sortKey="Wang, Shun Ping" sort="Wang, Shun Ping" uniqKey="Wang S" first="Shun-Ping" last="Wang">Shun-Ping Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0573 0731</institution-id><institution-id institution-id-type="GRID">grid.410764.0</institution-id><institution>Department of Orthopaedics,</institution><institution>Taichung Veterans General Hospital,</institution></institution-wrap>Taichung, 407 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taichung</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Fu Chou" sort="Cheng, Fu Chou" uniqKey="Cheng F" first="Fu-Chou" last="Cheng">Fu-Chou Cheng</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0573 0731</institution-id><institution-id institution-id-type="GRID">grid.410764.0</institution-id><institution>Stem Cell Medical Research Center, 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Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Heng Li" sort="Huang, Heng Li" uniqKey="Huang H" first="Heng-Li" last="Huang">Heng-Li Huang</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0083 6092</institution-id><institution-id institution-id-type="GRID">grid.254145.3</institution-id><institution>School of Dentistry, College of Medicine,</institution><institution>China Medical University,</institution></institution-wrap>91 Hsueh-Shih Road, Taichung, 40402 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>91 Hsueh-Shih Road, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9263 9645</institution-id><institution-id institution-id-type="GRID">grid.252470.6</institution-id><institution>Department of Bioinformatics and Medical Engineering,</institution><institution>Asia University,</institution></institution-wrap>Taichung, 413 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taichung</wicri:regionArea></affiliation></author><author><name sortKey="Tsai, Ming Tzu" sort="Tsai, Ming Tzu" uniqKey="Tsai M" first="Ming-Tzu" last="Tsai">Ming-Tzu Tsai</name><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1770 3722</institution-id><institution-id institution-id-type="GRID">grid.411432.1</institution-id><institution>Department of Biomedical Engineering,</institution><institution>Hungkuang University,</institution></institution-wrap>Taichung, 433 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taichung</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Jui Ting" sort="Hsu, Jui Ting" uniqKey="Hsu J" first="Jui-Ting" last="Hsu">Jui-Ting Hsu</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0083 6092</institution-id><institution-id institution-id-type="GRID">grid.254145.3</institution-id><institution>School of Dentistry, College of Medicine,</institution><institution>China Medical University,</institution></institution-wrap>91 Hsueh-Shih Road, Taichung, 40402 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>91 Hsueh-Shih Road, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9263 9645</institution-id><institution-id institution-id-type="GRID">grid.252470.6</institution-id><institution>Department of Bioinformatics and Medical Engineering,</institution><institution>Asia University,</institution></institution-wrap>Taichung, 413 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taichung</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Musculoskeletal Disorders</title><idno type="eISSN">1471-2474</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Intermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip. However, whether it can be used to treat osteoporosis of the mandible is unclear. The purpose of this study was to explore the influence of applying intermittent PTH to ovariectomized rats on the trabecular bone microarchitecture of the mandible and femoral head.</p></sec><sec><title>Methods</title><p>Eighteen female rats were divided into three groups: the healthy group, ovariectomized (OVX) group, and OVX + PTH group. The OVX group and OVX + PTH group had an OVX at 8 weeks of age. The OVX + PTH group received intermittent PTH therapy for 12 weeks. The mandibles and femurs of all rats were removed at 20 weeks and were then scanned using microcomputed tomography (micro-CT).</p></sec><sec><title>Results</title><p>From the micro-CT analysis, the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The bone volume fraction and trabecular thickness in the OVX group were lower than those in the healthy group. (2) The bone volume fraction and trabecular thickness in the OVX + PTH group approximated those in the healthy group.</p></sec><sec><title>Conclusion</title><p>The conclusions of this study regarding the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The BV/TV and TbTh in the OVX group were lower than those in the healthy group. (2) The BV/TV and TbTh in the OVX + PTH group approximated those in the healthy group, therefore, intermittent PTH displayed high efficacy for treating femoral or mandibular deterioration of bone microstructure resulting from loss of ovarian function. Osteoporosis of the femur or mandible in the rats was ameliorated by intermittent PTH therapy.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kanis, Ja" uniqKey="Kanis J">JA Kanis</name></author><author><name sortKey="Melton, Lj" uniqKey="Melton L">LJ Melton</name></author><author><name sortKey="Christiansen, C" uniqKey="Christiansen C">C Christiansen</name></author><author><name sortKey="Johnston, Cc" uniqKey="Johnston C">CC Johnston</name></author><author><name sortKey="Khaltaev, N" uniqKey="Khaltaev N">N Khaltaev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, Nc" uniqKey="Wright N">NC Wright</name></author><author><name sortKey="Looker, Ac" uniqKey="Looker A">AC Looker</name></author><author><name sortKey="Saag, Kg" uniqKey="Saag K">KG Saag</name></author><author><name sortKey="Curtis, Jr" uniqKey="Curtis J">JR Curtis</name></author><author><name sortKey="Delzell, Es" 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last="Hsu">Pei-Yu Hsu</name><name sortKey="Huang, Heng Li" sort="Huang, Heng Li" uniqKey="Huang H" first="Heng-Li" last="Huang">Heng-Li Huang</name><name sortKey="Huang, Heng Li" sort="Huang, Heng Li" uniqKey="Huang H" first="Heng-Li" last="Huang">Heng-Li Huang</name><name sortKey="Li, Yu Fen" sort="Li, Yu Fen" uniqKey="Li Y" first="Yu-Fen" last="Li">Yu-Fen Li</name><name sortKey="Tsai, Ming Tzu" sort="Tsai, Ming Tzu" uniqKey="Tsai M" first="Ming-Tzu" last="Tsai">Ming-Tzu Tsai</name><name sortKey="Wang, Shun Ping" sort="Wang, Shun Ping" uniqKey="Wang S" first="Shun-Ping" last="Wang">Shun-Ping Wang</name><name sortKey="Wu, Jay" sort="Wu, Jay" uniqKey="Wu J" first="Jay" last="Wu">Jay Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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